Table 1.

Descriptive statistics of molecular biomarker values as measured by immunohistochemistry in nonneoplastic tissues and tumors

Pretreatment ALL
Pretreatment CPR
Pretreatment PPR
Posttreatment PPR
NTNTNTNT
Bcl-245.4 (26.7)21.7 (18.9)47.3 (31.1) [3.2-97.8]18.4 (16.5) [0.6-47.1]44.8 (25.4) [1.2-97.8]22.9 (19.8) [0-83.6]55.4 (27.6) [8.8-96.2]35.5 (23.7) [0.3-87.2]
Bcl-xL43.8 (20.5)35.5 (27.3)50.1 (13.6) [39.9-65.5]37.7 (28.4) [0.1-7.3]41.5 (22.3) [1.4-71.2]34.8 (27.3) [0.7-99.8]42.4 (25.6) [0.1-92]39.9 (30.4) [0.9-95.4]
EGFR28.1 (25.0)27.7 (25.3)19.4 (16.0) [0.7-45.2]29.6 (26.1) [0.1-76.1]31.3 (27.0) [0.1-95.3]27.1 (25.3) [0.1-98.7]30.3 (22.5) [0.4-81.1]35.5 (26.6) [0.9-782]
ER35.6 (26.3)24.9 (26.8)35.1 (24.6) [1.7-79.2]22.9 (20.0) [0.8-65]35.8 (27.2) [0.9-91.2]25.6 (29.2) [0-98]42.3 (25.1) [0.1-93.4]31.2 (25.1) [0-84.2]
PR36.4 (26.6)40.3 (33.8)36.9 (26.7) [3.9-84.0]46.2 (35.9) [0-88.1]36.2 (27.0) [0-89.7]38.2 (33.3) [0-91.3]32.5 (21.3) [0-93.4]37.0 (26.7) [0.9-83.8]
Ki-6717.9 (23.8)39.6 (25.4)19.9 (17.0) [0.2-53.3]47.6 (28.7) [0.9-95.4]17.1 (26.0) [0-95.2]36.6.(24.0) [0.9-87.5]7.1 (11.9) [0.1-42.6]24.3 (22.9) [0-88.7]
pY-Src25.7 (24.4)49.0 (28.0)19.5 (24.2) [0.9-77.9]58.4 (25.6) [0.9-88.5]28.0 (24.4) [0-95.2]45.5 (28.5) [0.1-97.7]31.8 (26.9) [0.5-93.4]53.5 (30.2) [0.9-98.1]
pY-Stat327.8 (17.3)52.1 (26.8)22.8 (15.8) [0.8-53.8]40.6 (21.0) [0.9-78.4]29.7 (17.7) [0.9-89.7]56.4 (27.7) [0.9-98.5]24.6 (14.4) [0.1-64.8]53.6 (25.9) [0.9-92.9]
TUNEL34.9 (27.0)23.9 (24.8)43.3 (28.9) [0.9-100]22.4 (20.9) [0.9-67.5]31.7 (26.0) [0.9-65.8]24.5 (26.4) [0.1-76.2]30.4 (22.3) [0.9-61.5]21.5 (22.8) [0.9-84.3]
HER2/neu*39.1 (27.6)29.0 (24.4) [0.6-79.6]42.6 (28.1) [0.1-89.5]41.6 (22.9) [0.1-89.2]
Survivin*25.8 (24.4)29.4 (27.6) [1.3-71.3]23.8 (23.3) [0-76.3]NA
  • NOTE: The analysis was done for all patients as a group (ALL) as well as in the subgroups of complete pathologic responders and partial pathologic responders before and after chemotherapy treatment. All values are expressed as an index with a range between 0 and 100 reflecting relative intensities of staining for each biomarker. Data are means with SD in parentheses for all groups and ranges in brackets for the complete pathologic response and partial pathologic response subgroups only. There was no detectable expression of Survivin or HER2/neu in normal breast epithelium.

    Abbreviations: N, nonneoplastic tissues; T, tumors; CPR, complete pathologic responders; PPR, partial pathologic responders; NA, not available.

  • * No detectable levels of Survivin or HER2/neu were observed in nonneoplastic tissues; NA, not available.