Table 2.

Statistical analysis (P values) of differences in biomarker values between tumors and paired nonneoplastic tissues

Pretreatment
Posttreatment
ALLCPRPPRPPR
Bcl-2<0.0010.016<0.0010.003
Bcl-xL0.0670.1970.1910.710
EGFR0.9500.2550.5520.394
ER0.0380.0160.1390.036
PR0.5470.5230.7860.433
Ki-670.0010.0010.0060.001
pY-Src<0.0010.0010.0030.003
pY-Stat3<0.0010.010<0.001<0.001
HER2/neu*
Survivin*
TUNEL0.0540.0840.2650.061
  • NOTE: Analysis was done in the entire group of patients (ALL) and in the subgroups of complete pathologic responders and partial pathologic responders before and after chemotherapy treatment.

  • * No detectable levels of Survivin or HER2/neu were observed in nonneoplastic tissues.