Table 1.

Vd of [125I]BD-L8A4 following i.c. injection or CED in non-tumor-bearing rats

GroupRouteInfusion
Vd (mm3)Vd/Vi ratioRecovery of infusate
Time (min)Volume (mm3)Rate (mm3/min)
1i.c.210.05.010.8 ± 3.11.1 ± 0.3.87.1 ± 6.8
2CED155.00.3331.6 ± 5.86.3 ± 1.290.1 ± 8.2
3CED3010.00.3360.8 ± 11.46.1 ± 1.388.3 ± 5.6
4CED6020.00.33118.5 ± 19.25.9 ± 0.685.9 ± 4.3
  • NOTE: Vd was determined by quantitative autoradiography, and percentage recovery was determined by γ-scintillation in groups of four animals each. Means and SDs of Vd, Vd/Vi ratios, and percentage recovery were calculated.