Table 2.

Radiolocalization of [125I]BD-L8A4 in F98 glioma-bearing rats at 24 hours following either i.t. injection or CED

Tumor/route%ID/g
Tumor/brain ratio
TumorBrain ipsilateralBrain contralateralLiverBlood
F98npEGFRvIII/CED60.1 ± 10.86.2 ± 1.22.0 ± 0.50.19 ± 0.050.05 ± 0.019.5 ± 2.6
F98npEGFRvIII/i.t.43.7 ± 6.15.6 ± 1.12.9 ± 1.10.19 ± 0.050.06 ± 0.036.9 ± 1.3
F98 WT/CED14.6 ± 2.72.9 ± 1.21.2 ± 0.50.22 ± 0.080.05 ± 0.015.6 ± 2.6
F98WT/i.t.15.2 ± 3.43.2 ± 1.01.0 ± 0.50.34 ± 0.060.10 ± 0.024.9 ± 1.0
  • NOTE: Each animal received 5 μCi [125I]BD-L8A4 (50 μg L8A4) by either i.t. or CED. %ID/g was based on the amount recovered relative to that given. The tumor/brain ratio was based on tumor uptake versus ipsilateral (tumor-bearing) cerebral hemisphere.