Table 4.

Survival times of F98npEGFRvIII glioma-bearing rats following CED or i.t. injection of BD-L8A4 with or without i.v. BPA and BNCT

GroupRoute/agentSurvival times (d)
% Increased life span*
RangeMean ± SEMedianMeanMedian
1CED/BD-L8A4 (n = 11)41 to >180 (n = 1)70.4 ± 11.158168123
2CED/BD-L8A4 + i.v./BPA (n = 10)42 to >180 (n = 2)85.5 ± 15.565.5225152
3i.v./BPA (n = 8)32-5240.1 ± 2.2405254
4CED/L8A4 + irradiation (n = 7)24-3730.3 ± 1.6301515
5CED/BD-L8A4 (n = 7)21-3426.3 ± 1.626
  • * Percentage of increased life span was defined relative to MST and median survival time of untreated controls.

  • n is the number of rats surviving >180 days.