Table 3.

Depsipeptide-related adverse events reported in all 15 patients

Adverse eventGrade 1
Grade 2
Grade 3
n (%)
Gastrointestinal
    Anorexia3 (20)8 (53)
    Nausea5 (33)6 (40)2 (13)
    Vomiting4 (27)5 (33)1 (7)
    Dyspepsia/bloating2 (13)2 (13)
    Dysgeusia3 (20)3 (20)
    Diarrhea2 (13)2 (13)1 (7)
    Dry mouth2 (13)
Constitutional
    Fatigue4 (27)6 (40)1 (7)
    Weight loss3 (20)1 (7)
    Fever2 (13)
    Rigors1 (7)1 (7)
Cardiopulmonary
    Palpitations1 (7)
    Ventricular tachycardia2 (13)
    QTc prolongation3 (20)3 (20)
    ST depression/T-inversion5 (33)
    T-wave flattening2 (13)
    Hypotension1 (7)
    Dyspnea1 (7)1 (7)
    Dizziness2 (13)
Hematologic
    Anemia3 (20)2 (13)2 (13)
    Thrombocytopenia7 (46)2 (13)
    Neutropenia1 (7)
    Lymphopenia5 (33)4 (27)
Hepatic
    Elevated AST/ALT4 (27)1 (7)
    Hyperbilirubinemia3 (20)1 (7)
Miscellaneous
    Hypocalcemia4 (27)1 (7)
    Blurry vision2 (13)
    Orbital cellulitis1 (7)
  • NOTE: Grade 4 to 5 adverse events: one grade 4 lymphopenia and one grade 5 sudden death.

    Abbreviations: AST, aspartate aminotransferase; ALT, aspartate aminotransferase.