Table 3.

Association of cetuximab IC50 with molecular markers of ErbB signaling

EGFRErbB2ErbB3EGFR copy no.Gefitinib IC50
Correlation coefficient−0.640.010.27−0.630.36
P0.048*0.990.450.0530.31

pEGFR
pErbB2
pErbB3
pAkt
pErk
Correlation coefficient−0.470.44−0.19−0.03−0.15
P0.170.200.590.930.70
  • NOTE: Quantity of ErbB and pErbB signals was estimated by densitometric analysis of Western films. Associations were calculated using Spearman correlation coefficients.

  • * P < 0.05, n = 10, except for pAkt and pErk (n = 9).