Table 2.

Association of gefitinib IC50 with molecular markers of ErbB signaling

EGFRErbB2ErbB3EGFR copy no.Cetuximab IC50
Correlation coefficient−0.470.590.71−0.630.36
P0.170.070.02*0.0498*0.31

pEGFR
pErbB2
pErbB3
pAkt
pErk
Correlation coefficient−0.440.71−0.08−0.10−0.12
P0.200.02*0.830.800.77
  • NOTE: Quantity of ErbB and pErbB signals was estimated by densitometric analysis of Western films. Associations were calculated using Spearman correlation coefficients.

  • * P < 0.05, n = 10, except for pAkt and pErk (n = 9).