Table 4.

Median (range) plasma rhIL-18 pharmacokinetic variables

rhIL-18 dose, μg/kg (n)Day 1 AUC (h × ng/mL)Day 5 AUC (h × ng/mL)Accumulation ratioAccumulation t1/2 (h)
3 (3)214 (122-247)461 (273-479)2.24 (1.87-2.24)30 (24-42)
10 (4)353 (228-465)881 (704-1,045)2.27 (1.85-4.57)31 (19-94)
30 (3)771 (490-858)2,099 (2,076-2,250)2.69 (2.62-4.29)37 (36-38)
100 (5)627 (574-852)1,993 (1,774-2,790)3.27 (2.49-3.70)41 (27-61)
200 (3)869 (884-904)2,252 (1,627-3,108)2.55 (1.87-3.44)36 (31-37)
300 (3)1,983 (1,255-2,392)5,527 (2,715-6,357)2.31 (2.22-3.21)35 (30-44)
600 (3)3,443 (3,379-3,869)6,192 (5,393-6,456)1.60 (1.57-1.91)26 (25-30)
1,000 (3)5,941 (5,941-8,523)9,945 (9,308-17,362)1.67 (1.57-2.04)36 (34-36)
  • Abbreviation: AUC, area under the plasma concentration versus time curve.