Table 2.

PFS for patients with <5 or ≥5 CTC at different time points

CTC/7.5 mLBaseline
3-5 weeks
6-8 weeks
9-14 weeks
15-20 weeks
<5≥5<5≥5<5≥5<5≥5<5≥5
Patients, n (%)90 (51)87 (49)89 (71)37 (29)73 (83)15 (17)91 (89)11 (11)64 (85)11 (15)
Median PFS, mo (95% CI)7.0 (5.8-8.9)2.7 (2.1-4.4)6.1 (4.7-8.6)1.3 (0.7-2.1)5.6 (4.5-7.6)1.4 (0.6-3.4)7.0 (5.1-8.8)3.0 (0.9-4.8)6.0 (3.8-8.7)3.6 (0.7-6.7)
Log-rank P0.0001<0.00010.00010.01340.0424
Cox hazard ratio (95% CI)1.89 (1.37-2.61)2.31 (1.53-3.47)3.03 (1.68-5.48)2.26 (1.16-4.42)2.01 (1.01-4.01)
P0.00010.00010.00090.03010.0660
PD within 3 months (%)*205419681953NPNPNPNP
Fisher's exact P<0.001<0.0010.009NPNP
PD within 6 months (%)*40684376407325551727
Fisher's exact P<0.0010.0010.0230.0710.420
  • Abbreviations: PD, progressive disease; NP, not performed.

  • * Progressive disease within 3 or 6 months from the time of the baseline blood draw.

  • Nine to 14 weeks and 15 to 20 weeks are blood draws taken at roughly the 3-month time point and after.