Table 3.

OS for patients with <5 or ≥5 CTC at different time points

CTC/7.5 mLBaseline
3-5 weeks
6-8 weeks
9-14 weeks
15-20 weeks
<5≥5<5≥5<5≥5<5≥5<5≥5
Patients, n (%)90 (51)87 (49)91 (69)41 (31)77 (78)22 (22)105 (81)24 (19)70 (83)14 (17)
Median OS, mo (95% CI)21.9 (20.1 to >25)10.9 (6.4-15.1)21.0 (18.8 to >25)6.3 (4.1-10.2)18.6 (14.2 to >25)6.3 (4.8-9.8)21.5 (17.8 to >25)6.6 (3.0-10.9)>25 (17.1 to >25)6.7 (2.0-22.9)
Log-rank P<0.0001<0.00010.0001<0.00010.0013
Cox hazard ratio (95% CI)2.45 (1.64-3.65)3.37 (2.13-5.34)2.80 (1.62-4.85)3.88 (2.27-6.64)3.09 (1.50-6.34)
P<0.0001<0.00010.0006<0.00010.0048
Death within 6 months (%)*7347391023529321
Fisher's exact P<0.001<0.0010.1560.0010.031
Death within 12 months (%)*1853196623731567950
Fisher's exact P<0.001<0.001<0.001<0.0010.001
  • * Death within 6 or 12 months from the time of the baseline blood draw.