Table 1.

Effects of SD-208 treatment on gene expression in normal liver

Gene nameGenbankUnigene IDGene Ontology biological processGene Ontology molecular function
Actin-related protein 2/3 complex, subunit 1BBC010275.1Q91Z25Regulation of actin cytoskeletonWD repeat
BC003441.1
AF162768.1
NM_023142.1
Actinin, α1BE853286Q99LJ3Biological process unknownActin binding
Anaphase-promoting complex subunit 5AI842295ANC5_MOUSEUbiquitin cycleMolecular function unknown
BCL2-associated transcription factor 1BB833538BCF1_MOUSENegative regulation of transcriptionDNA binding
Caldesmon 1BC019435.1Q8VCQ8Regulation of smooth muscle contractionActin binding
Calmodulin 3NM_007589.1O93622G-protein-coupled receptor protein signaling pathwayCalcium ion binding
AW543361
AI256814
Core promoter element-binding proteinBG800611KLF6_MOUSERegulation of transcription, DNA dependentZinc ion binding
BC020042.1
NM_011803.1
Damage-specific DNA-binding protein 1NM_015735.1Q99LV3DNA repairDamaged DNA binding
AB026432.1
AF159853.1
E26 avian leukemia oncogene 1, 5′ domainBB151715Q8BVW8Cellular processBinding
Erythrocyte protein band 4.1-like 2BG075070Q80UE5Cortical actin cytoskeleton organization and biogenesisSpectrin binding
Forkhead box P1BM220880Q6P221Regulation of transcription, DNA dependentZinc ion binding
BB479687
Glucosaminyl (N-acetyl) transferase 2, I-branching enzymeBM236768BGIB_MOUSENullN-acetyllactosaminide β-1,6-N-acetylglucosaminyltransferase activity
AB037596.1
Glutathione synthetaseNM_008180.1GSHB_MOUSEGlutathione biosynthesisGlutathione synthase activity
BB125219
BC003784.1
U35456.1
High mobility group box 1BF166000HMG1_RATCell organization and biogenesisHeparin binding
NM_010439.1
BC008565.1
Hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase, α subunitAW107842Q5U5Y5Fatty acid β-oxidationEnoyl-CoA hydratase activity
Integrin β1 (fibronectin receptor β)U37029.1Q61126G1-S transition of mitotic cell cycleReceptor activity
Jumonji domain containing 1CAV293164Q8C4I5NullNull
LIM and SH3 protein 1BB105164LAS1_MOUSENullZinc ion binding
AV027151
MARCKS-like proteinNM_010807.1Q5U2A3NullCalmodulin binding
BC006757.1
AV215438
Myeloid cell leukemia sequence 1NM_008562.1P97287ApoptosisProtein binding
BC003839.1
U35623.1
BC021638.1
BC005427.1
BB374534
AV274748
Neuropilin 1NM_008737.1NRP1_MOUSEAngiogenesisReceptor activity
D50086.1
AK002673.1
AK011144.1
Peroxisome proliferative-activated receptor, γ, coactivator 1αBB752393Q8CCT1Cellular lipid metabolismTranscription coactivator activity
BB745167
Rap guanine nucleotide exchange factor 2AK018008.1Q6NXI4Protein kinase cascadeMetal ion binding
Ring finger protein (C3H2C3 type) 6BI738010Q8K565Positive regulation of transcription, DNA dependentDNA binding
RNA-binding motif, single-stranded interacting protein 1AW541585RBS1_MOUSERegulation of translationssDNA binding, dsDNA binding
SEC63-like (Saccharomyces cerevisiae)BC019366.1Q8K2U5Protein foldingUnfolded protein binding
Syndecan 1NM_011519.1SDC1_MOUSENullObsolete molecular function
BB533095
Thyroid hormone receptor-associated protein 3BC012655.1Q8R353Positive regulation of transcription from Pol II promoterTranscription coactivator activity
BB531820
Tight junction protein 2BB758095Q95M46NullProtein binding
TGF-β1-induced transcript 4AU016382Q5U2A0Regulation of transcription, DNA dependentTranscription factor activity
BB357514
AF201285.1
V-ral simian leukemia viral oncogene homologue B (ras related)BB465250RALB_MOUSESmall GTPase-mediated signal transductionGTPase activity
  • NOTE: Genes that were found to be significantly repressed in mouse livers by SD-208 treatment were compared with the profile of genes reported previously to be induced by TGF-β in NMuMG mouse mammary epithelial cells in vitro (13). The table lists the 31 genes that were represented in both sets along with their assigned molecular function and biological process (Gene Ontology database).