Table 1.

Correlation between FLT tumor uptake and histologic proliferative markers in published literature

StudyDisease siteProliferation correlation
FDG correlation
MarkerCorrelation
Barthel et al. (15)*FibrosarcomaPCNAr = 0.71r = 0.53
Waldherr et al. (19)*SCCaPCNAr = 0.71r = 0.74
Leyton et al. (16)*FibrosarcomaPCNAr = 0.89r = 0.55
Wagner et al. (44)*LymphomaBrdUrd*r = 0.63
Ki-67r = 0.95
Vesselle et al. (45)LungKi-67r = 0.84
Buck et al. (42)LungKi-67r = 0.92r = 0.59
Francis et al. (43)ColonKi-67r = 0.80r = 0.40
Cobben et al. (46)SarcomaKi-67r = 0.65
van Westreenen et al. (38)EsophagealKi-67r = −0.76r = 0.14
  • Abbreviations: BrdUrd, bromodeoxyuridine; PCNA, proliferating cell nuclear antigen; SCCa, squamous cell carcinoma.

  • * Preclinical.

  • Clinical.