Table 2.

Methylation frequency (%) of eight gene loci according to histology

p16MGMTMLH1APCBRCA1RARβ2CDH1DAPKMeth ≥1 geneMeth ≥2 genes
Normal (n = 17)066000180290
ED1 (n = 39)31238331310285133
ED2 (n = 12)421717003317255842
ED3 (n = 9)331133004433115656
ESC (n = 69)52332313283634269170
P*<0.0010.0130.10.19<0.0010.0010.060.09<0.001<0.001
  • Abbreviations: Normal, normal esophagus; ED1, low-grade esophageal dysplasia; ED2, intermediate-grade dysplasia; ED3, high-grade esophageal dysplasia/carcinoma in situ.

  • * Using Mantel-Haenszel χ2 test for trends.