Table 3.

Methylation changes of eight loci in multiple lesions from individual patients

ED1Gene(s) methylatedED2Gene(s) methylatedED3Gene(s) methylatedESCGene(s) methylatedChange
108None36None0
119None77None0
127None89None0
120D44None−1
129None51B1
125None94R1
121None40C1
144None95None48R1
90None81A1
142None58R, E2
124None105E, R2
126None25M, B2
122None73None65C, B2
146None61E, B, D3
140None91C, E, R, D4
147None84A, R, B, C4
98C52C0
71C56C0
130C, D117C23C, A1, −1
131C, L, D50C, E1, −2
128C, D102C, D, R113D, R72C, D, R1
110C68C, B, D2
136C, M67C, M, E, R2
97C93C, M, L, R3
103M79M, B, R, E3
109C, R, D, E148C, R, D, E, M1
123R, E, D22R, E, D, C1
106R, E, D82E, L92R, E, L, M, D2
101R, D, L38R, L, M, E, B, C4, −1
132C, M, D85C, M, B, E2, −1
133M, R, B, D, C, E74M, R, B, D−2
  • NOTE: Each line represents an individual with sample number (in bold) to the left of the alterations observed at each loci. The number of changes during progression is summarized to the right with negative numbers indicating losses of methylation.

    Abbreviations: C, CDKN2A/p16; M, MGMT; L, MLH1; D, DAPK; E, E-cadherin/CDH1; R, RARβ2; B, BRCA1; A, APC.