Table 2.

Hypokalemia grade by dose level and incidence and days of potassium supplementation by dose level

Test/LBH589 cohort (mg/m2)Total, nCTCAE grade 3
CTCAE grade 4
Totaln (%)Totaln (%)
Hypokalemia
    4.8331 (33.3)30 (0)
    7.2330 (0)30 (0)
    9.0111 (100)10 (0)
    11.5331 (33.3)30 (0)
    14.0550 (0)51 (20.0)
    Total15153 (20.0)151 (6.7)
Dose level (mg/m2)
Average no. days on LBH589 therapy
Average no. days patients required potassium supplementation
4.871.3
7.25.64.3
9.0710
11.55.38
14.054