Table 3.

Pharmacokinetic variable estimates by a noncompartmental analysis after the first dose (mean ± SD)

DayDose (mg/m2)Tmax (h)Cmax (ng/mL)AUC0-24 (h ng/mL)AUC0-8 (h ng/mL)t1/2 (h)
14.8 (n = 3)0.4 ± 0.1182.3 ± 62.7143.1 ± 62.6158.3 ± 75.87.8 ± 5.0
7.2 (n = 3)0.4 ± 0.1120.7 ± 10.1134.9 ± 7.09150.7 ± 9.58.0 ± 2.1
9.0 (n = 1)0.5201.0194.5240.913.9
11.5 (n = 3)0.4 ± 0.2249.3 ± 147.4295.5 ± 97.3322.8 ± 122.39.5 ± 6.3
14.0 (n = 5)0.4 ± 0.1565.6 ± 450.9372.9 ± 196.9459.6 ± 242.612.0 ± 2.8