Table 1.

Summary of immunohistochemical examination of histone acetylation (AcH3 and AcH4), markers associated with neuronal (MAP-2 and synaptophysin) and glial (GFAP) differentiation, and intermediate filaments (VMT) in xenografts treated with or without valproic acid

MarkersICb-D283
ICb-DAOY
ICb-MED-1
UntreatedTreatedUntreatedTreatedUntreatedTreated
AcH3+/−, 30%+, 90%+/−, 10%+, 50%+, 15%+, 70%
AcH4+, 25%+, 80%(−)+, 5%+, 20%+, 85%
MAP-2++, 5%+++, 30%+, 20%++, 70%+++, 50%+++, 75%
Synaptophysin++, 50%++, 60%+, 5%+, 5%+, 10%+, 10%
GFAP(−)(−)(−)(−)(−)(−)
VMT+++, 85%+++, 80%+++, 100%+++, 100%+++, 90%+++, 70%