Summary of immunohistochemical examination of histone acetylation (AcH3 and AcH4), markers associated with neuronal (MAP-2 and synaptophysin) and glial (GFAP) differentiation, and intermediate filaments (VMT) in xenografts treated with or without valproic acid
| Markers | ICb-D283 | ICb-DAOY | ICb-MED-1 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Untreated | Treated | Untreated | Treated | Untreated | Treated | ||||
| AcH3 | +/−, 30% | +, 90% | +/−, 10% | +, 50% | +, 15% | +, 70% | |||
| AcH4 | +, 25% | +, 80% | (−) | +, 5% | +, 20% | +, 85% | |||
| MAP-2 | ++, 5% | +++, 30% | +, 20% | ++, 70% | +++, 50% | +++, 75% | |||
| Synaptophysin | ++, 50% | ++, 60% | +, 5% | +, 5% | +, 10% | +, 10% | |||
| GFAP | (−) | (−) | (−) | (−) | (−) | (−) | |||
| VMT | +++, 85% | +++, 80% | +++, 100% | +++, 100% | +++, 90% | +++, 70% | |||