Table 1.

Dose escalation schema

Dose tierCI-1033 dose (mg)No. of patientsTotal no. of cycles/cohortNo. of first cycle DLTs/cohort
Schedule A
    1105220
    220330
    3306120
    4455120
    567.5340
    6100380
Schedule B
    710037.50
    815088.251
    9225*7270
    10337.5792
    115003<1 cycle each2
  • * Maximum tolerated dose.

  • Maximum administered dose.