Table 3.

Summary of toxicities (all grades) encountered during the study with an incidence of 15% or more

Daily dose (mg)
All patients (n = 53) no. of patients (%)
3 days per week for 4 weeks on/2 weeks off (Schedule A)
3 days per week continuously (Schedule B)
10 (n = 5)20 (n = 3)30 (n = 6)45 (n = 5)67.5 (n = 3)100 (n = 3)100 (n = 3)150 (n = 8)225 (n = 7)337.5 (n = 7)500 (n = 3)
Cutaneous toxicities222123857234 (64)
Pain3224524224 (45)
Asthenia21121123114 (26)
Nausea231223114 (26)
Vasodilation*226212 (23)
Stomatitis11132311 (21)
Dyspnea11211111110 (19)
Myalgia122121110 (19)
Vomiting11322110 (19)
Diarrhea211329 (17)
Infection1211319 (17)
Thrombocytopenia131128 (15)
  • * Vasodilation implies facial flushing, lightheadedness, orthostasis, or dizziness.