Variable | Canertinib-Cl-1033 | ||||
---|---|---|---|---|---|

I.v. | Oral | ||||

MTD | MTD | Bioequivalent | |||

Dose | 225 | 500 | 725 | ||

K_{el} | 0.232 | 0.157 | 0.157 | ||

t_{1/2} | 3.2 | 4.4 | 4.4 | ||

t_{max} | 0.4 | 2.3 | 2.3 | ||

C_{max} | 2233 | 265 | 384 | ||

AUC | 3,518 | 2,385 | 3,458 | ||

VD | 371 | 1,336 | 1,336 | ||

CL | 73 | 210 | 210 | ||

F (%) | 31 | 31 |

Abbreviations: K

_{el}, elimination rate constant expressed in hours^{-1};*t*_{1/2}, plasma half-life hours;*t*_{max}, time the maximum concentration occurs in hours; C_{max}, maximum concentration expressed as ng/mL; AUC, area under the curve expressed as ng × Hr/mL; VD, volume of distribution expressed in liters (L); CL, clearance expressed as ng/h; F, fraction of drug absorbed expressed as a percentage.