Table 4.

GO categories that discriminate IBC and non-IBC, with permutation P < 0.005

GO categoryGO descriptionNo. genesLS permutation PKS permutation P
10003823Antigen binding341e−051e−05
20006525Arginine metabolism90.000120.001
30006787Porphyrin catabolism70.000191e−04
40030333Antigen processing350.000361e−05
50006527Arginine catabolism70.000360.00146
60004129Cytochrome c oxidase activity260.000380.00304
70015002Heme-copper terminal oxidase activity260.000380.00304
80016675Oxidoreductase activity, acting on heme group of donors260.000380.00304
90016676Oxidoreductase activity, acting on heme group of donors, oxygen as acceptor260.000380.00304
100000051Urea cycle intermediate metabolism106e−040.00296
110016813Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines70.000860.00168
120019882Antigen presentation440.000941e−05
130050660FAD binding90.001030.00602
140019883Antigen presentation, endogenous antigen170.001091e−05
150019885Antigen processing, endogenous antigen via MHC class I170.001091e−05
160000313Organellar ribosome250.001310.00315
170005761Mitochondrial ribosome250.001310.00315
180006778Porphyrin metabolism250.001540.01142
190044270Nitrogen compound catabolism90.001590.01364
200008147Structural constituent of bone60.001850.02226
210046483Heterocycle metabolism570.002110.03156
220050662Coenzyme binding230.002280.01673
230006081Aldehyde metabolism120.002990.18169
240004062Aryl sulfotransferase activity60.003350.00038
250045012MHC class II receptor activity230.003611e−05
260008194UDP-glycosyltransferase activity590.003930.03168
270019835Cytolysis50.003940.07823
280015020Glucuronosyltransferase activity110.003980.00913
290005750Respiratory chain complex III (sensu Eukaryota)50.003980.00451
300006743Ubiquinone metabolism50.003990.00398
310006744Ubiquinone biosynthesis50.003990.00398
320042375Quinone cofactor metabolism50.003990.00398
330045426Quinone cofactor biosynthesis50.003990.00398
340016782Transferase activity, transferring sulfur-containing groups320.004010.00066
350005583Fibrillar collagen180.004220.00038
360051017Actin filament bundle formation50.004290.14763
370004029Aldehyde dehydrogenase (NAD) activity120.004290.17928
380006354RNA elongation90.00430.03916
390008146Sulfotransferase activity280.004520.00015
400007585Respiratory gaseous exchange130.004740.0064
410000050Urea cycle60.004810.02556
420008021Synaptic vesicle200.005540.00043
430008210Estrogen metabolism50.005740.00065
440004075Biotin carboxylase activity60.008240.00037
450007269Neurotransmitter secretion50.01110.00155
460016421CoA carboxylase activity60.012260.00017
470005540Hyaluronic acid binding170.012360.00244
480016885Ligase activity, forming carbon-carbon bonds70.013670.00015
490016706Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors70.014380.00125
500006584Catecholamine metabolism140.017890.00275
510018958Phenol metabolism140.017890.00275
520005581Collagen340.019020.00085
530000096Sulfur amino acid metabolism240.019080.00125
540019884Antigen presentation, exogenous antigen170.031150.00044
550004385Guanylate kinase activity130.041640.00396
560016282Eukaryotic 43S preinitiation complex370.044450.00087
570019886Antigen processing, exogenous antigen via MHC class II180.044810.00192
580006941Striated muscle contraction180.056680.00382
590006817Phosphate transport480.062971e−05
600016805Dipeptidase activity60.075430.00398
610015698Inorganic anion transport890.126960.00122