Table 1.

Comparison of IL-6, pStat3, and IL-6R expression in parent and multidrug-resistant cancer cell lines

Cell lineIL-6 (pg/mL)pStat3IL-6R
SKOV-3/SKOV-3TR35/2,100*+
Caov-3/Caov-3TR400/1,400N/M
OV1063/OV1063TR820/980N/M
OVCAR5/OVCAR5TR400/360+
OVCAR8/OVCAR8TR360/380+
SW626/Sw626TR6/150+
IGROV-1/IGROV-1TR6/70N/M
U-2OS/U-2OSTR12/50+
A2780/A2780CP703/3N/M
  • * Culture supernatants were collected and IL-6 levels were analyzed by ELISA. Data represent the average value of triplicate experiments.

  • An upward arrow indicates the expression was higher in drug-resistant cell lines as compared with sensitive cell lines. “−” indicates expression were nearly equal in drug-resistant cell lines as compared with sensitive cell lines. pStat3 expression was determined by Western blot analysis.

  • “+” indicates positive expression of IL-6R. “N/M” indicates not measured. IL-6R expression was determined by quantitative reverse transcription-PCR.