Table 1.

Response to targeted therapy in mouse models of APL

Genetic modificationResponse to RAResponse to RA + As2O3Response to RA + HDAC inhibitor
PML-RARαCRCRCR
PLZF-RARαNRNRCR
NPM-RARαCR
  • Abbreviations: RA, retinoic acid; As2O3, arsenic trioxide; HDAC, histone deacetylase; CR, complete response; NR, nonresponsive.