Table 2.

Photofrin uptake in normal and tumor tissues as a function of tissue site

Tissue sitePhotofrin concentration (ng/mg)
Normal median (range, n)Tumor median (range, n)
Appendix3.95 (NA, n = 1)NA
Fat1.21 (0.5-1.8, n = 11)4.25 (4.0-4.5, n = 2)
Gall bladder3.51 (3.2-3.8, n = 2)NA
Large intestine mucosa5.75 (4.8-6.7, n = 2)NA
Large intestine with mucosa2.62 (1.2-4.4, n = 12)NA
Large intestine without mucosa1.77 (0.9-2.7, n = 4)NA
Left upper quadrantNA3.07 (NA, n = 1)
Liver36.9 (34.9-38.9, n = 2)1.71 (NA, n = 1)
Mesentery2.68 (NA, n = 1)2.87 (2.0-4.9, n = 5)
Muscle0.82 (NA, n = 1)NA
Omental bursa0.96 (0.3-3.0, n = 15)3.91 (1.5-4.2, n = 4)
Other1.70 (1.4-2.0, n = 6)2.06 (0.4-6.0, n = 37)
Pancreas1.70 (1.4-2.0, n = 2)NA
PelvisNA3.54 (NA, n = 1)
Peritoneum3.60 (NA, n = 1)2.93 (0.6-5.3, n = 2)
Small intestine mucosa3.61 (2.6-4.3, n = 4)NA
Small intestine with mucosa2.99 (0.3-11.9, n = 23)NA
Small intestine without mucosa1.94 (0.8-2.8, n = 5)0.66 (NA, n = 1)
Skin0.91 (0.3-2.3, n = 4)NA
Spleen21.5 (15.7-23.2, n = 3)4.71 (3.8-5.6, n = 2)
Stomach2.4 (1.0-2.5, n = 3)2.95 (1.9-4.0, n = 2)
  • NOTE: Tumor or normal tissue was collected from each listed tissue site in the i.p. cavity. Values indicate median Photofrin uptake among patients, with the range in values and the number of patients (n) indicated in parentheses.

    Abbreviation: NA, not available.