Table 1.

EGFR status and gefitinib sensitivity of the cell lines used in this study

Cell lineGefitinib IC50 (╬╝mol/L)EGFR status
A4310.2Wild-type, amplification (14, 15)
A54911.9Wild-type (15)
H19757.1L858R, T790M (16)
H3255<0.2L858R (6)
HCC4006<0.2Exon 19 deletion (17)
  • NOTE: IC50 values were calculated from growth curve assays done on cell lines treated for 4 days with various concentrations of gefitinib.