Table 4.

Steady-state plasma DAC levels during continuous 72-hour infusion

Cohort 1 (60 mg/m2)
Cohort 2 (75 mg/m2)
Cohort 3 (90 mg/m2)
Patient no.CycleDrug level (mean ± SD)Patient no.CycleDrug Level (mean ± SD)Patient no.CycleDrug Level (mean ± SD)
1110.56 ± 2.38418.35 ± 1.8418110.1 ± 3.6
318.96 ± 1.41819.33 ± 1.961918.25 ± 2.55
1017.31 ± 1.9917.35 ± 2.2521110.97 ± 4.23
1316.16 ± 2.114111.05 ± 2.892218.91 ± 1.82
2315.49 ± 1.92417.34 ± 2.07
2325.30 ± 1.762519.37 ± 1.11
2336.47 ± 1.9125210.78 ± 2.13
2715.25 ± 1.1