Table 1.

Summary of the consequences of sustained delivery of 1,25 D3

Experimental groupNNormalLow-grade PIN*High-grade PIN with invasionP
Wild-type—vehicle4400
Wild-type—1,25 D38800
Precancerous mutant—vehicle8008
Precancerous mutant—1,25 D3120102<0.001
Cancerous mutant—vehicle8008
Cancerous mutant—1,25 D38017
  • * Criteria for designating low-grade and high-grade PIN are described in ref. 25; see Materials and Methods for details about how the phenotype of the mice is evaluated.

  • The P value shown compares the precancerous mutant mice in the vehicle-treated or 1,25 D3–treated groups; none of the other groups showed a significant difference in phenotypic outcome.