Table 2.

The combination of 268, and either Arz or Acol, prevents ER− mammary gland tumors in MMTV-neu transgenic mice (52-week study)

TreatmentControlArz, 6 mg/kg diet268, 30 mg/kg dietArz + 268Acol, 3 mg/kg dietAcol + 268
No. of mice/group241212121212
No. of mice with tumors (%)24 (100)7* (58)7* (58)0* (0)8* (67)0* (0)
Total no. of tumors/group377100120
Average no. of tumors/mouse1.50.6*0.80*1.00*
  • * P < 0.05 versus control.

  • P < 0.05 versus Arz, 268, and Acol.

  • P < 0.05 versus Acol.