Table 2.

Mean, interindividual, and interday variability, and covariate models of imatinib and CGP 74588 pharmacokinetic variables

Final covariate model*Mean (±95% CI)%CV
Imatinib
    Clearance: CL (L/h) = 𝛉1 (AAG/1.15)𝛉2𝛉1 = 7.97 (±0.93); 𝛉2 = −0.52 (±0.15)29
    Volume of distribution: V (L) = 𝛉3𝛉3 = 168 (±35)62
    Duration of zero order absorption: D1 = 𝛉4𝛉4 = 2.53 (±1.39)80
        Interoccasion variability of D138
CGP 74588
    Clearance: CLm/fm (L/h) = 𝛉5 (AAG/1.15)𝛉6 × 𝛉7OCC𝛉5 = 58.6 (±5.6); 𝛉6 = −0.60 (±0.19); 𝛉7 = 0.55 (±0.05)23
Volume of distribution: Vm/fm (L) = 𝛉8𝛉8 = 15.4 (±3.21)72
Alternative covariate models
Mean (±95% CI)
ΔOBJ
P
%CV
CL = 𝛉1𝛉1 = 8.13 (±1.26)+62<0.00138
CLm/fm = 𝛉5𝛉1 = 44.1 (±8.5)+135<0.00132
CLm/fm = 𝛉5 × 𝛉7OCC𝛉5 = 54.6 (±7.9); 𝛉7 = −0.62 (±0.06)+60<0.00136
CLm/fm = 𝛉5 (AAG/1.15)𝛉6𝛉5 = 43.3 (±4.8); 𝛉6 = −0.41 (±0.30)+118<0.00121
  • Abbreviation: CI, confidence interval

  • * AAG: plasma AAG level (g/L); occasion with OCC equal to 0 if pharmacokinetic data were obtained on day 1, or equal to 1 on day ≥30.

  • Coefficient of variation for interindividual variability (not explained by the covariate, if any) or interoccasion variability.

  • Change in objective function by comparison with the final covariate model.