Table 2.

Dose escalation and hematologic values for cycle 1 and all cycles

Dose level17-AAG (mg/m2/dose)No. patientsMedian ANC nadir x10 9/L (range)Median WBC nadir x10 9/L (range)Median platelet nadir x10 9/L (range)
Cycle 1
    15714.45.8326
    28014.17.0254
    311213.04.5159
    415714.48.0250
    52206*3.7 (3.1-4.5)5.8 (4.2-7.0)226 (139-386)
    630823.8 (3.6-4.1)5.7 (5.2-6.2)431 (297-565)
All cycles
    15714.25.8297
    28014.17.0236
    311213.04.1135
    415713.55.1147
    52206*3.1 (2.6-4.3)5.0 (3.8-6.9)231 (84-362)
    630823.8 (3.6-4.1)5.7 (5.2-6.2)427 (297-557)
  • Abbreviation: ANC, absolute neutrophil count.

  • * Seven patients were treated at 220 mg/m2, however, data from only six patients are available.