Table 1.

Sites of disease and treatment history

PatientPrior treatmentMetastatic disease status on enrollment in study
1Hysterectomy, BSO, debulked, Taxol, Carboplatin, Cisplatin, bone marrow transplant, etoposideLower abdominal s.c. mass, two inguinal nodules
2THA/BSO, omentectomy, appendectomy, nodectomy, Taxol, Cisplatin, Topotecan, HexamethylmelamineRetroperitoneal and left cervical lymph nodes
3Radical hysterectomy, debulked, Carboplatin, Cytoxan, Adriamycin, Mitoxantrane, Tamoxifen, etoposide, radiationLiver and vaginal cuff
4TAH/BSO Taxol, Carboplatin, Doxil, Topotecan, GemzarPerihepatic lesion, midabdominal s.c. nodule
5TAH/BSO, Carboplatin, Cytoxan, Taxol, TopotecanPerihepatic, ascites, sigmoid mass, omental disease
6Debulked, Carboplatin, Taxol, DoxilPelvic mass, para-aortic adenopathy
7TAH/BSO, debulked, Carboplatin, TaxolMultiple sites periaortic retroperitoneal adenopathy
8TAH/BSO, debulked, Cisplatin, Cytoxan, Carboplatin, Taxol, Topotecan, DoxelLiver, pericolonic, pelvic lymph node
9TAH/BSO, debulked, Carboplatin, Taxol, CytoxanLiver and rectal muscle mets
10TAH/BSO, debulked, Carboplatin, Taxol, Cisplatin, Taxol, monoclonal vaccine, TamoxifenOmentum, peritoneal implants, diaphragm, right supraclavicular nodes, pelvis
11TAH/BSO, omentectomy, appendectomy, pancreatic reduction, splenectomy, Cytoxan, Cisplatin, vincristine, Hexalen, etoposide, Taxol, Carboplatin, Adriamycin, Topotecan, GemzarPeritoneal implants, left pleural effusion, liver, retroperitoneal nodes
12TAH/BSO, omentectomy, Taxol, Carboplatin, bone marrow transplant, Taxane, Doxil, Herceptin, Gemcitabine, TopotecanPelvic and mediastinal mets
13Ovarian cystectomy, hysterectomy, pelvic lymphadenectomy, Taxotere, Carboplatin, Topotecan, Doxyl, GemzarOmentum, mediastinum
14TAH/BSO, omentectomy, pelvic and para-aortic lymphadenectomy, Taxol, Cisplatin, external beam radiation, Topotecan, Thalidomide, etoposide, HexalenEpigastric intra-abdominal mass, right pelvic mass
  • NOTE: Patients had advanced ovarian cancer with metastases to various sites. Before enrolling in the current study, total abdominal hysterectomy and bilateral salpingo-oophorectomy were done, and most patients had undergone debulking surgery (patients 1-8 enrolled in cohort 1 and patients 9-14 in cohort 2).

    Abbreviations: TAH, total abdominal hysterectomy; BSO, bilateral salpingo-oophorectomy.