Table 3.

Cumulative fecal and urinary excretion (0-24 hours) of paclitaxel, 3′-p-hydroxypaclitaxel, and 6α-hydroxypaclitaxel in intact mice after i.v. administration of [3H]paclitaxel at 10 mg/kg

Biological matrixCompoundStrain
WTMdr1a/1b−/−Mrp2−/−Mdr1a/1b/Mrp2−/−
FecesPaclitaxel49.0 ± 4.41.4 ± 0.6*30.8 ± 8.11.0 ± 0.3*
3′-p-Hydroxypaclitaxel14.8 ± 1.217.2 ± 1.39.9 ± 1.91.6 ± 0.5*
6-α-Hydroxypaclitaxel8.4 ± 0.69.7 ± 0.85.1 ± 1.60.6 ± 0.2*
[3H] label68.2 ± 1.649.0 ± 4.5*46.8 ± 7.8*21.6 ± 3.2*
UrinePaclitaxel0.66 ± 0.180.58 ± 0.210.73 ± 0.070.77 ± 0.13
3′-p-HydroxypaclitaxelNDND0.02 ± 0.010.02 ± 0.01
6-α-HydroxypaclitaxelNDND0.04 ± 0.020.15 ± 0.01
[3H] label3.3 ± 0.65.4 ± 0.814.5 ± 1.7*27.1 ± 3.3*
  • NOTE: Excretion is given as percentage of the dose (mean ± SD, n = 5).

    Abbreviation: ND, not detectable.

  • * P < 0.001, compared with WT mice.

  • P < 0.01, compared with WT mice.

  • P <0.05, compared with WT mice.