Table 3.

HR-HPV–positive oropharygeal SCC

CasePhysical status E2/E6mRNA
TP53/p53
Homozygous deletion
9p21 FISHCyclin D1 IHCEGFR
p15INK4b
p14ARF/p16INK4a
E6E7TP53 mutIHCExon lExon 2Exon 1βExon 1αExon 2IHCFISHMutation
1Mixed0.31++wtNNNNNDisomyHighDisomywt
2Mixed0.04++wtNHDNNNDisomyHighDisomywt
3Mixed0.06++Gly199Arg/GGA>AGANENENENNEDisomyHighDisomywt
4Mixed0.03++wtNNNNNDisomyIntermediateHEDwt
5Mixed0.2++wtNNNNNDisomyHighDisomywt
6Mixed0.2++wt<20%NNNNNDisomyHighDisomyNE
7Mixed0.09++wtNNNNNDisomyHighDisomywt
8Mixed0.04++wtNNNNNDisomyIntermediateDisomywt
9Mixed0.05++wtNNNNNDisomyHighDisomywt
10Mixed0.02++wtNNNNNDisomyHighDisomywt
11Mixed0.04++Asp281Asn/GAC>AAC80%NNNNNDisomyNEHighDisomywt
12Mixed0.01++wtNENENENENEDisomy60%IntermediateDisomywt
13Mixed0.03++wt<20%NHDHDNNDisomyIntermediateMonosomyNE
14Mixed0.04++wtNENENENENEDisomyHighDisomywt
15Integrated/ND++wtNNHDNNDisomyHighDisomywt
16ND++wt<20%NNNNNEDisomyIntermediateMonosomiawt
17Integrated++wtNNNENNDisomyIntermediateHigh polysomywt
100%12%6%20%0%100%6%0%
  • Abbreviations: ND, not done; +, positive; −, negative; IHC, immunohistochemistry; N, normal; HD, homozygous deletion; NE, not evaluable; HED: hemizygous deletion.