Table 5.

HR-HPV–negative TP53 wild-type oropharyngeal SCC

CaseTP53/p53
Homozygous deletion
9p21 FISHcyclin D1 IHCEGFR
p15INK4b
p14ARF/p16INK4a
TF53 mutIHCExon 1Exon 2Exon 1βExon 1αExon 2IHCFISHMutation
51wt20%NENENENENEDisomyLow polysomyND
52wt30%NENENENENENE20%LowNEND
53wt20%NHDHDNEHDMonosomy40%IntermediateHigh polysomyND
54wt30%NENENENENEDisomy80%IntermediateLow polysomywt
55wt30%NHDHDHDHDHD30%LowHigh polysomyND
56wt20%NHDNNNDisomyIntermediateDisomywt
57wt30%NENENENENEDisomy30%IntermediateDisomyND
58wt30%HDHDHDHDHDHEDIntermediateDisomyND
59wtNNNNNHDHighHigh polysomywt
60wtNNNNNDisomy40%HighHigh polysomyND
61wtNHDHDHDNHDIntermediateLow polysomyND
62wtNENENENENEHED40%HighDisomywt
63wtNNnvNNHD70%IntermediateHigh polysomyND
64wtNlowlowlowNEHEDHighDisomyND
65wtNENENENENEDisomyIntermediateDisomyND
66wtNENENENENENEIntermediateNEND
67wtNNNNNHD30%HighDisomywt
68wtNHDHDHDHDHDIntermediateDisomyND
69wtNNHDHDHDHDHighDisomyND
70wtNHDHDnaHDDisomy30%NENEND
71wtHDHDHDHDHDHD>70%HighDisomyND
72wtNNNNNDisomyIntermediateLow polysomyND
73wtNNNNNDisomyHighDisomyND
74wtNHDHDHDHDMonosomy20%HighHigh polysomyND
75wtNENENENENEMonosomy50%HighDisomyND
76wtNENENENENEHD40%IntermediateDisomyND
77wtNENENENENEHDnvLowNEND
78wtNHDHDHDHDHEDIntermediateDisomyND
79wtHDHDlowlowNEDisomyIntermediateDisomyND
80wtHDHDHDHDHDMonosomy60%HEDND
81wtNNNNNHD30%HighDisomywt
82wtNHDHDHDHDHDHighLow polysomyND
83wtNNNNNDisomyHighDisomywt
84wtHDHDHDNENENEIntermediateDisomyND
85wtNNNNNHDHighLow polysomywt
86wtNHDNNNDisomyIntermediateDisomywt
87wtNHDHDNNDisomyLowLow polysomywt
88wtNHDHDNNDisomy70%HighDisomyND
89wtNHDHDHDHDHD20%DisomyND
90wtNENENENENEHDHighLow polysomywt
65%62%10%82%39%
  • Abbreviations: ND, not done; +, positive; −, negative; IHC, immunohistochemistry; N, normal; HD: homozygous deletion; NE: not evaluable; HED, hemizygous deletion.