Localization and function of human Aurora kinases
| Phase | Localization | Function | Putative substrates | |||
|---|---|---|---|---|---|---|
| Aurora-A | ||||||
| G1 | Undetectable | NA | TACC, centrosomin, SPD-2. XMAP215, γ TuRC, Ajuba. Eg5, Ran-TPX2, CENP-A, PP1, p53. CDH1. NM23-H1, CPEB | |||
| Late S phase | Duplicated centrosomes | Centrosome maturation | ||||
| G2 | Duplicated centrosomes | Mitotic entry | ||||
| Prophase | Duplicated centrosomes | Centrosome separation | ||||
| Prometaphase | Spindle poles | Bipolar-spindle assembly | ||||
| Metaphase | Spindle poles | Chromosome alignment on the metaphase plate | ||||
| Anaphase | Spindle midzone/centrosomes | Cytokinesis | ||||
| Telophase | Spindle midzone/centrosomes | Cytokinesis | ||||
| Aurora-B | ||||||
| G1 | Undetectable | NA | INCEP, survivin, Borealin, MCAK, BubR1, Mad2, CHO1/MKLP-1/ZEN4, myosin II regulatory light chain, vimentin, desmin, Histone H3, CENP-A, REC-8, RACGAP1, GF AP, CPEB | |||
| G2 | Undetectable | NA | ||||
| Prophase | Nucleus | Recruitment of centromeric proteins | ||||
| Prometaphase | Kinectochores | Recruitment of centromeric proteins | ||||
| Chromosome biorientation and segregation | ||||||
| Metaphase | Kinectochores | Mitotic checkpoint | ||||
| Anaphase | Spindle midzone | Cytokinesis | ||||
| Telophase | Spindle midzone/Cleavage-furrow | Cytokinesis | ||||
Abbreviation: NA, not available.