Table 1.

Localization and function of human Aurora kinases

PhaseLocalizationFunctionPutative substrates
Aurora-A
    G1UndetectableNATACC, centrosomin, SPD-2. XMAP215, γ TuRC, Ajuba. Eg5, Ran-TPX2, CENP-A, PP1, p53. CDH1. NM23-H1, CPEB
    Late S phaseDuplicated centrosomesCentrosome maturation
    G2Duplicated centrosomesMitotic entry
    ProphaseDuplicated centrosomesCentrosome separation
    PrometaphaseSpindle polesBipolar-spindle assembly
    MetaphaseSpindle polesChromosome alignment on the metaphase plate
    AnaphaseSpindle midzone/centrosomesCytokinesis
    TelophaseSpindle midzone/centrosomesCytokinesis
Aurora-B
    G1UndetectableNAINCEP, survivin, Borealin, MCAK, BubR1, Mad2, CHO1/MKLP-1/ZEN4, myosin II regulatory light chain, vimentin, desmin, Histone H3, CENP-A, REC-8, RACGAP1, GF AP, CPEB
    G2UndetectableNA
    ProphaseNucleusRecruitment of centromeric proteins
    PrometaphaseKinectochoresRecruitment of centromeric proteins
Chromosome biorientation and segregation
    MetaphaseKinectochoresMitotic checkpoint
    AnaphaseSpindle midzoneCytokinesis
    TelophaseSpindle midzone/Cleavage-furrowCytokinesis
  • Abbreviation: NA, not available.