Table 3.

Aurora kinases in current clinical trials

AgentTargetsClinicalTrials.gov identifierSponsorPatient population
MK0457Pan Aurora kinase inhibitionNCT00099346Merck & Co.Advanced cancer
Pan Aurora kinase inhibitionNCT00104351Merck & Co.Advanced cancer
FLT3 inhibitionNCT00104351Merck & Co.Relapsed or refractory leukemia
Pan Aurora kinase inhibitionNCT00290550Merck & Co.Advanced non-small cell lung cancer
MLN8054Aurora-A inhibitionNCT00249301Millennium PharmaceuticalsAdvanced solid tumors
AZD1152Aurora-B inhibitionNCT00338182AstraZenecaAdvanced solid tumors
PHA-739358Pan Aurora kinase inhibitionNCT00335868Nerviano Medical SciencesRelapsed chronic myelogenous leukemia