Table 3.

Mean urinary recovery of vorinostat and two inactive metabolites following oral administration of single or multiple oral of 400 mg

DoseDietNAnalyteUrinary recovery, mean % dose (SD)Total recovery (% dose)
400 mg single doseFasted22Vorinostat0.2 (0.1)34.9
OG-V10.7 (5.9)
4A4OA24.0 (8.6)
400 mg single doseFed21Vorinostat0.3 (0.2)50.5
OG-V18.2 (6.2)
4A4OA31.9 (10.6)
400 mg once daily × 22 dFed12Vorinostat0.4 (0.2)52.3
OG-V15.9 (5.9)
4A4OA36.0 (8.6)
  • Abbreviations: 4A4OA, 4-anilino-4-oxobutanoic acid; OG-V, O-glucuronide of vorinostat.