Table 2.

Adverse events during therapy with IL-2 and rituximab

Organ SystemGrade
1234
Constitutional
    Chills30 (53%)8 (14)
    Fatigue20 (35)21 (37)3 (5)
    Fever16 (28)6 (11)
Cardiovascular1 (2)1 (2)1 (2)*
Dermatologic
    Injection site reaction18 (32)13 (23)
Gastrointestinal22 (39)17 (30)1 (2)
    Nausea21 (37)11 (19)
    Vomiting
    Diarrhea11 (19)
Hematologic5 (9%)2 (4)2 (4)
Infectious8 (14)6 (11)
Metabolism18 (32)4 (7)2 (4)
    Anorexia12 (21)3 (5)
Musculoskeletal16 (28)10 (18)5 (9)
    Myalgia12 (21)4 (7)1 (2)
Nervous system11 (19)8 (14)1 (2)
    Dizziness4 (7)4 (7)
    Headache4 (7)3 (5)
Pulmonary19 (33)8 (14)2 (4)1 (2)
    Cough8 (14)3 (5)
    Dyspnea4 (7)3 (5)1 (2)
  • * Myocardial infarction.

  • Cerebral vascular accident.

  • Pulmonary embolism.