Table 3.

Five-year RFS rates (95% CI) and AHRs for SHS exposure

LocationQuartile of SHS exposure (duration, y)
P*
Quartile 1Quartile 2Quartile 3Quartile 4
All exposures (y)<2828-3738-46>46
N/deaths99/5499/5799/6296/72
5-y survival rate (%)58 (47-68)54 (53-64)43 (32-53)39 (29-50)0.004
Crude HR1.001.10 (0.76-1.60)1.33 (0.93-1.92)1.82 (1.27-2.59)<0.001
AHR model1.001.03 (0.70-1.50)1.08 (0.74-1.58)1.38 (0.94-2.03)0.10
Home exposure (y)<2222-3637-53>53
N/deaths103/6393/52100/6197/69
5-y survival rate (%)50 (40-60)55 (44-66)48 (37-58)42 (32-52)0.25
Crude HR1.000.85 (0.59-1.23)1.06 (0.75-1.51)1.23 (0.88-1.73)0.14
AHR model 11.000.90 (0.61-1.31)1.05 (0.72-1.53)1.15 (0.81-1.65)0.34
AHR model 21.000.95 (0.64-1.41)1.12 (0.76-1.64)1.13 (0.77-1.67)0.62
Work exposure (y)<77-3031-42>42
N/deaths101/4995/63104/6293/71
5-y survival rate (%)59 (49-70)40 (29-51)55 (45-65)37 (27-47)<0.001
Crude HR1.001.60 (1.10-2.32)1.25 (0.86-1.82)2.15 (1.45-3.11)<0.001
AHR model 11.001.37 (0.93-2.01)1.09 (0.74-1.60)1.60 (1.08-2.37)0.07
AHR model 21.001.45 (0.97-2.18)1.08 (0.72-1.62)1.66 (1.09-2.52)0.13
Leisure exposure (y)<3636-4849-60>60
N/deaths99/5795/52106/7293/64
5-y survival rate (%)55 (44-65)59 (49-70)40 (30-50)41 (30-51)0.002
Crude HR1.000.86 (0.59-1.25)1.46 (1.030-2.06)1.58 (1.10-2.27)0.001
AHR model 11.000.77 (0.52-1.14)1.16 (0.81-1.67)1.19 (0.81-1.76)0.16
t1AHR model 21.000.67 (0.45-1.01)1.00 (0.68-1.48)0.96 (0.63-1.48)0.38
  • NOTE: In all of the analyses, the quartile 1 group was treated as the reference group, and age, stage, and pack-years of smoking were included in the adjusted Cox proportional hazard model (reference category).

  • * The P values were for log-rank test or trend test in Cox models, respectively.

  • Home, work, and leisure exposures were analyzed in separate models.

  • Home, work, and leisure exposures were analyzed in the same model.