Table 3.

Expression of BUB1B by immunohistochemistry in breast cancer tissues

Histologic typeNo. testedNo. (%) positive
Grade 1 ductal407 (18%)
Grade 2 ductal7665 (86%)
Grade 3 ductal137129 (94%)
Mucinous60
Lobular117 (64%)
  • NOTE: Cases with 0 or 1+ staining (similar to normal breast tissue) are classified as negative, and cases with 2+ or 3+ staining are classified as positive. The percentages of positive cases for grade 1 ductal and mucinous breast cancers are significantly less (P << 0.001 by χ2 statistic) than for grade 2 and 3 ductal breast cancers. Overall, 77% of tumors stained positive for BUB1B.