Table 2.

Effects on cell cycle distribution in NSCLC cell lines sensitive (IC50, <1 μmol/L), intermediate (IC50, 3-6 μmol/L), and resistant (IC50, ≥8 μmol/L) after 24-hour exposure to 1 and 10 μmol/L gefitinib

Response to gefitinibCell lineIC50 (μmol/L)Gefitinib (μmol/L)MFI%G1G0-G1 (%)S (%)G2-M (%)
SensitiveH32250.01507.364342
0.1319550
1329622
H16480.38011.7453124
12267330
103075250
Calu30.308.9433520
11962326
104471340
H3220.25016413821
19503218
1030711910
H3580.1804355312
18434611
1023583012
IntermediateCOLO6994.200513316
102778157
H21225.905.1393922
1025642610
H14353014384814
1023612910
H441606433918
1017602713
NE185016522721
1010622018
H1253013433819
109523315
ResistantA5499.6014434314
101053389
H1703801549429
10756368
H15712.8013434017
104473914
H46012.9012493714
103503416
H52013.600404317
101394318
H2261004961390
10061372