Table 1.

Relationships between EGFR family members and their ligands

ReceptorSynonymsLigandDimerization partnerKinase activity
EGFRErbB1, HER1EGF, TGF-α, HB-EGF, AR, BTC, ERP, decorinEGFR, HER2, HER4+
HER2ErbB2, neuEGFR, HER3, HER4+
HER3ErbB3NRG-1HER2, HER3, HER4
HER4ErbB4NRG-1, NRG-2, NRG-3, NRG-4EGFR, HER2, HER3, HER4+
  • Abbreviations: HB-EGF, heparin-binding EGF; AR, amphiregulin; BTC, betacellulin; EPR, epiregulin.