Table 2.

Effects of castration and ZD6474 treatment in the ipsilateral ventral prostate lobe inoculated with AT-1 tumor cells

Intact day 7* (n = 6)Intact day 10* (n = 10-15)Castrated day 10* (n = 14-18)ZD6474 day 10 (n = 8-13)ZD6474 + castrated day 10* (n = 8-13)
Ventral prostate weight (both lobes, mg)251 ± 79263 ± 59191 ± 58242 ± 58169 ± 21§
Apoptosis index (tumor-bearing lobe, %)0.051 ± 0.00270.17 ± 0.052.6 ± 0.930.15 ± 0.0762.4 ± 0.54§
Proliferation index (tumor-bearing lobe, %)1.4 ± 0.591.9 ± 0.942.7 ± 0.711.7 ± 0.782.9 ± 0.63§
Volume density of blood vessels (tumor-bearing lobe, %)1.4 ± 0.541.8 ± 0.321.4 ± 0.241.5 ± 0.271.1 ± 0.21§
Apoptosis index (tumor-embedded glands, %)NA0.76 ± 0.482.4 ± 0.981.5 ± 0.722.1 ± 0.50§
  • * Days after AT-1 tumor cell inoculation. Therapy with castration and/or ZD6474 was given from day 7. For details, see Materials and Methods. Values are presented as means ± SD.

  • Significantly different than in controls at day 10, P < 0.05.

  • Significantly different than in castrated animals at day 10, P < 0.05.

  • § Significantly different than in ZD6474-treated animals at day 10, P < 0.05.

  • Significantly different than in controls at day 7, P < 0.05.