Effects of castration and ZD6474 treatment in the ipsilateral ventral prostate lobe inoculated with AT-1 tumor cells
| Intact day 7* (n = 6) | Intact day 10* (n = 10-15) | Castrated day 10* (n = 14-18) | ZD6474 day 10 (n = 8-13) | ZD6474 + castrated day 10* (n = 8-13) | |
|---|---|---|---|---|---|
| Ventral prostate weight (both lobes, mg) | 251 ± 79 | 263 ± 59 | 191 ± 58† | 242 ± 58‡ | 169 ± 21†§ |
| Apoptosis index (tumor-bearing lobe, %) | 0.051 ± 0.0027 | 0.17 ± 0.05∥ | 2.6 ± 0.93† | 0.15 ± 0.076‡ | 2.4 ± 0.54†§ |
| Proliferation index (tumor-bearing lobe, %) | 1.4 ± 0.59 | 1.9 ± 0.94 | 2.7 ± 0.71† | 1.7 ± 0.78‡ | 2.9 ± 0.63†§ |
| Volume density of blood vessels (tumor-bearing lobe, %) | 1.4 ± 0.54 | 1.8 ± 0.32∥ | 1.4 ± 0.24† | 1.5 ± 0.27† | 1.1 ± 0.21†‡§ |
| Apoptosis index (tumor-embedded glands, %) | NA | 0.76 ± 0.48 | 2.4 ± 0.98† | 1.5 ± 0.72†‡ | 2.1 ± 0.50†§ |
↵* Days after AT-1 tumor cell inoculation. Therapy with castration and/or ZD6474 was given from day 7. For details, see Materials and Methods. Values are presented as means ± SD.
↵† Significantly different than in controls at day 10, P < 0.05.
↵‡ Significantly different than in castrated animals at day 10, P < 0.05.
↵§ Significantly different than in ZD6474-treated animals at day 10, P < 0.05.
↵∥ Significantly different than in controls at day 7, P < 0.05.