Table 2.

TSP-1 peptide mimetics are biologically active against canine endothelial cells

ABT-510 (pmol/L)Percentage of chemotaxis inhibition*
HMVECDog BOECDog DEN-HAS
10,00070 ± 579 ± 899 ± 1
1,00053 ± 762 ± 1178 ± 4
10030 ± 553 ± 578 ± 7
10<1034 ± 163 ± 18
1<10<1057 ± 8
0.1<10<10<10
  • Abbreviations: HMVEC, human microvascular endothelial cells; BOEC, blood outgrowth endothelial cell; DEN-HAS, canine hemangiosarcoma cell line.

  • * Mean percentage of endothelial cell chemotaxis inhibition, normalized against untreated cells (±SE for triplicate experiments). Each experiment was repeated at least twice.