Table 4.

Frequency of methylated genes according to clinicopathologic features

CharacteristicsNo. patients*HLTFHPP1hMLH1
% PositiveP% PositiveP% PositiveP
Size of tumor0.030.0210.047
    T1 + T2 + T390281120
    T413462346
Nodal status0.5140.0260.494
    N05420624
    N149222022
Distant metastases0.009<0.0010.181
    M08616526
    M117475312
Localization0.0490.1560.100
    Right252412
    Left§78201427
    Colon60150.05470.061220.408
    Rectum43301926
Grading0.8720.7960.316
    G133300
    G253211319
    G345221329
UICC stage0.042<0.0010.648
    I1520727
    II3415324
    III3716527
    IV17475312
  • * For one patient, tumor localization and information on TNM staging was not available.

  • P values were calculated by the χ2 test.

  • Right colon includes cecum through transverse colon.

  • § Left colon includes descending colon through rectum.

  • Relative risk was calculated for G3 versus G1 and G2. G3 includes all cases classified as G3 or G2-G3.