Table 2.

Correlation of serum MCP-1 levels with known clinical prognostic variables in breast cancer patients

Study no.Serum MCP-1 levelAgeRaceGrade of tumorStage 2 or aboveTumor T2 or aboveNode-positiveNo. nodesEstrogen/progesterone receptor +/+HER-2/neu oncogene 3+ by IHCChemotherapy
MCP-low
    NNV1528.858WhiteNoNoNo0YesNoNo
    B5440.845WhitePoorYesYesYes4YesYesYes
    B5747.862WhitePoorYesNoYes1NoYesYes
    NNV1150.1945OtherPoorNoNoNo0NoNoYes
    NNV2259.3753WhiteNoNoNo0No
    NNV2362.746WhitePoorYesYesNo0YesNoYes
    B4670.752WhiteModYesNoYes2NoYesYes
    NNV680.3546WhiteModNoNoNo0YesNoYes
    NNV485.953WhiteModNoNoNo0YesNoYes
    NNV1986.450OtherModNoNoNo0YesNoYes
    B419349WhiteWellYesNoYes2YesNoYes
    B5697.2743WhitePoorYesNoYes6NoYesYes
    NNV14123.3374WhiteModNoNoNo0YesNo
    B5313550WhiteModYesNoYes2NoNoYes
    B50136.3351WhitePoorYesYesYes5NoNoYes
    B44155.3262OtherPoorYesYesYes3NoNoYes
    NNV20157.1855WhiteModNoNoNo0YesNoNo
    NNV13178.0852WhitePoorYesYesNo0YesYesYes
    NNV10196.757WhiteWellNoNoNo0YesNo
    NNV5230.1659OtherModNoNoNo0NoYesYes
    B51237.673WhiteWellYesNoYes1YesNoNo
    B55244.648WhitePoorYesYesYes8YesYesYes
MCP-high
    NNV12266.2361WhiteNoNoNo0NoYesNo
    NNV3281.1877OtherWellNoNoNo0YesNoNo
    NNV8285.2162WhiteWellNoNoNo0YesNoNo
    NN21287.658WhiteModNoNoNo0YesYesYes
    NNV24337.656WhiteWellNoNoNo0YesNoNo
    NNV18357.777WhitePoorNoNoNo0YesNoNo
    NNV17419.562OtherPoorNoNoNo0YesNoNo
    NNV7427.3850WhiteModNoNoNo0NoNoNo
    NNV9453.874WhiteModNoNoNo0YesNoNo
    NNV16617.3262WhiteNoNoNo0YesNo
  • NOTE: An arbitrary cutoff (250 pg/mL) in the serum MCP-1 levels was found to generally divide breast cancer patients into those with favorable and unfavorable clinical prognostic variables. NNV, node-negative patients; B, node-positive patients; Poor, poorly differentiated tumor; Mod, moderately differentiated tumor; Well, well-differentiated tumor; IHC, immunohistochemistry.