CD16 surface expression NK cells correlates with the frequency of NK cells in renal cell carcinoma tumors
| n* | %NK (range)† | %CD16+ (range)‡ | |
|---|---|---|---|
| NK-PBMC§ | 13 | 12.7 (2.0-26.0) | 89.5 (72.4-98.7) |
| NK-TIL∥ | 22 | 59.3 (24.8-96.9) | |
| High NK-TIL | 7 | 35.4 (22.0-62.1) | 89.9 (82.0-96.9)¶ |
| Low NK-TIL | 14 | 12.2 (5.9-17.9) | 43.5 (24.8-68.9)¶ |
↵* Number of lymphocyte populations investigated.
↵† Mean percentage (range) of CD3−CD56+ NK cells.
↵‡ Mean percentage (range) of CD16+ cells within gated CD3−CD56+ NK cells.
↵§ PBMC from renal cell carcinoma patients.
↵∥ TIL from renal cell carcinoma tissues, grouped according to their NK cell content (high-NK-TIL, >20% NK; low-NK-TIL, <20% NK).
↵¶ P value between both groups of NK-TIL was <0.0001 (other P values are given in the text).