Table 3.

Patterns of tumor antigen expression over time in 86 individuals with multiple samples

LostReducedAcquiredIncreasedNo changeFluctuatedAbsentTotal
gp1006 (7%)18 (21%)2 (2%)15 (17%)29 (34%)16 (19%)0 (0%)86 (100%)
Melan-A4 (5%)17 (20%)1 (1%)8 (9%)42 (49%)14 (16%)0 (0%)86 (100%)
Tyrosinase5 (6%)6 (7%)1 (1%)13 (15%)46 (53%)15 (17%)0 (0%)86 (100%)
MAGE-13 (3%)1 (1%)21 (24%)11 (13%)2 (2%)12 (14%)36 (42%)86 (100%)
MAGE-40 (0%)2 (2%)28 (33%)6 (7%)4 (5%)8 (9%)38 (44%)86 (100%)
NY-ESO-122 (26%)4 (5%)14 (16%)5 (6%)5 (6%)15 (17%)21 (24%)86 (100%)
  • NOTE: Lost, antigen that was initially present (usually within primary tumor) and was absent in subsequent sample(s). Reduced, antigen that was initially present and was present but in fewer cells within subsequent sample(s). Acquired, antigen that was absent in the initial sample and was present in subsequent sample(s). Increased, antigen in the initial sample was present in more cells in subsequent sample(s). Fluctuated, levels increased and decreased over the time course. Absent, antigen was never present.