Table 1.

BMS-345541 inhibits growth of melanoma cells in vitro

BMS-345541 (μmol/L)Normal human epidermal melanocytes (105)SK-MEL-5 (105)A375 (105)Hs 294T (105)
04.8 ± 0.234.0 ± 0.153.9 ± 0.322.0 ± 0.20
0.14.8 ± 0.283.7 ± 0.553.2 ± 0.381.9 ± 0.15
1.04.9 ± 0.382.7 ± 0.311.6 ± 0.382.2 ± 0.42
100.18 ± 0.040.028 ± 0.020.020 ± 0.010.013 ± 0.01
  • NOTE: 1 × 105 cells per well were plated in six-well plates with 10% fetal bovine serum medium overnight to allow cell adhesion. Cells were cultured in medium containing BMS-345541 at final concentrations of 0, 0.1, 1.0, and 10 μmol/L for 72 hours of treatment. Cells were counted with a hemocytometer.